Evaluating the weak in vivo micronucleus response of a genotoxic carcinogen, aristolochic acids.

doi:10.1016/j.mrgentox.2013.03.002

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Article

Evaluating the weak in vivo micronucleus response of a genotoxic carcinogen, aristolochic acids.

Mutation research - 15 May 2013

Bhalli Javed A, Ding Wei, Shaddock Joseph G, Pearce Mason G, Dobrovolsky Vasily N, Heflich Robert H

Abstract excerpt

Aristolochic acids (AAs) are carcinogenic plant toxins that are relatively strong gene mutagens, both in vitro and in vivo, but weak inducers of micronuclei in vivo. In order to clarify the reasons for these disparate responses, we evaluated the genotoxicity of AAs in F344 rats using several assays that respond to DNA damage in bone marrow. Groups of 7- to 8-week-old male rats (n=6) were gavaged with 0, 2.75,...

Topics

Animals
Aristolochic Acids
Bone Marrow
Carcinogens
Comet Assay
Erythrocytes
Hypoxanthine Phosphoribosyltransferase
Kidney
Liver
Lymphocytes
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Micronucleus Tests

Mutagenicity Tests

Mutation

Rats

Rats, Inbred F344

Reticulocytes

Weight Gain

Source

Open in PubMed

Identifiers

PMID: 23500662
DOI: 10.1016/j.mrgentox.2013.03.002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-23500662-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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