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Aristolochic acid suppresses DNA repair and triggers oxidative DNA damage in human kidney proximal tubular cells

27 May 2010

Abstract excerpt

Aristolochic acid (AA), derived from plants of the Aristolochia genus, has been proven to be associated with aristolochic acid nephropathy (AAN) and urothelial cancer in AAN patients. In this study, we used toxicogenomic analysis to clarify the molecular mechanism of AA-induced cytotoxicity in normal human kidney proximal tubular (HK-2) cells, the target cells of AA. AA induced cytotoxic effects in a...

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PMID: 20514455
DOI: 10.3892/or_00000839

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