Article
A variance component based multi-marker association test using family and unrelated data.
BMC genetics - 4 Mar 2013
Wang Xuefeng, Morris Nathan J, Zhu Xiaofeng, Elston Robert C
Abstract excerpt
BACKGROUND: Incorporating family data in genetic association studies has become increasingly appreciated, especially for its potential value in testing rare variants. We introduce here a variance-component based association test that can test multiple common or rare variants jointly using both family and unrelated samples. RESULTS: The proposed approach implemented in our R package aggregates or collapses the...
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