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Article

Rare variant analysis for family-based design.

PloS one - 1 Jan 2013

De Gourab, Yip Wai-Ki, Ionita-Laza Iuliana, Laird Nan

Abstract excerpt

Genome-wide association studies have been able to identify disease associations with many common variants; however most of the estimated genetic contribution explained by these variants appears to be very modest. Rare variants are thought to have larger effect sizes compared to common SNPs but effects of rare variants cannot be tested in the GWAS setting. Here we propose a novel method to test for association of...

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PMID: 23341868
DOI: 10.1371/journal.pone.0048495
PMCID: PMC3546113

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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