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Article

Robust rare variant association testing for quantitative traits in samples with related individuals.

Genetic epidemiology - 1 Jan 2014

Jiang Duo, McPeek Mary Sara

Abstract excerpt

The recent development of high-throughput sequencing technologies calls for powerful statistical tests to detect rare genetic variants associated with complex human traits. Sampling related individuals in sequencing studies offers advantages over sampling unrelated individuals only, including improved protection against sequencing error, the ability to use imputation to make more efficient use of sequence data,...

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PMID: 24248908
DOI: 10.1002/gepi.21775
PMCID: PMC4510991

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