Article
[Family-based association tests for rare variants].
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi - 10 Sept 2022
Chen X, Wang S Y, Xue E C, Wang X H, Peng H X, Fan M, Wang M Y, Wu Y Q, Qin X Y, Li J, Wu T, Zhu J, Li Z P, Zhou D F, Chen Y H, Hu Yonghua
Abstract excerpt
Next-generation sequencing has revolutionized family-based association tests for rare variants. As the lower power of genome wide association study for detecting casual rare variants, methods aggregating effects of multiple variants have been proposed, such as burden tests and variance component tests. This paper summarizes the methods of rare variants association test that can be applied for family data,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.