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Article

Variance-component-based meta-analysis of gene-environment interactions for rare variants.

G3 (Bethesda, Md.) - 6 Sept 2021

Jin Xiaoqin, Shi Gang

Abstract excerpt

Complex diseases are often caused by interplay between genetic and environmental factors. Existing gene-environment interaction (G × E) tests for rare variants largely focus on detecting gene-based G × E effects in a single study; thus, their statistical power is limited by the sample size of the study. Meta-analysis methods that synthesize summary statistics of G × E effects from multiple studies for rare...

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PMID: 34544119
DOI: 10.1093/g3journal/jkab203
PMCID: PMC8661424

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