Article
A one-shot germinal center model under protein structural stability constraints.
Physical biology - 1 Apr 2013
Raoof Sana, Heo Muyoung, Shakhnovich Eugene I
Abstract excerpt
The germinal center reaction is the process by which low-affinity B cells evolve into potent, immunoglobulin-secreting plasma and memory B cells. Since the recycling hypothesis was created, experimental studies have both tracked movement of a small population of B cells from the light zone into the dark zone, supporting the recycling model, and parallel to the light zone-dark zone interface, indicating a one-way...
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