Article

Replaying germinal center evolution on a quantified affinity landscape

2025-06-05

Abstract excerpt

<h4>ABSTRACT</h4> Darwinian evolution of immunoglobulin genes within germinal centers (GCs) underlies the progressive increase in antibody affinity following antigen exposure. Whereas the cellular mechanics of how competition between B cells produces increases in affinity are well established, the evolutionary dynamics of this process are less clear. We developed an experimental evolution model where we “replay”...

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Literature Corpus work: 5e4dc690-13d0-55f5-82ac-2cb0230f0dea
DOI: 10.1101/2025.06.02.656870

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