Article

Somatic mutation leads to efficient affinity maturation when centrocytes recycle back to centroblasts

1997-06-01

Abstract excerpt

Abstract Although most mutations are deleterious, an interplay between somatic mutation and selection within germinal centers (GC) results in rapid generation of high affinity memory B cells. How high affinity B cells with large numbers of mutations are generated and preserved within GC containing at their peak only a few thousand cells has been puzzling. We have developed a model of somatic mutation and B cell ex...

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Literature Corpus work: 1757a8ac-c4b0-5e69-b607-5426ef49a31a
DOI: 10.4049/jimmunol.158.11.5155

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