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Article

Somatic mutation leads to efficient affinity maturation when centrocytes recycle back to centroblasts.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jun 1997

Oprea M, Perelson A S

Abstract excerpt

Although most mutations are deleterious, an interplay between somatic mutation and selection within germinal centers (GC) results in rapid generation of high affinity memory B cells. How high affinity B cells with large numbers of mutations are generated and preserved within GC containing at their peak only a few thousand cells has been puzzling. We have developed a model of somatic mutation and B cell expansion...

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PMID: 9164931

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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