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Article

Germinal center dynamics during acute and chronic infection.

Mathematical biosciences and engineering : MBE - 1 Jun 2017

Erwin Samantha, Ciupe Stanca M

Abstract excerpt

The ability of the immune system to clear pathogens is limited during chronic virus infections where potent long-lived plasma and memory B-cells are produced only after germinal center B-cells undergo many rounds of somatic hypermutations. In this paper, we investigate the mechanisms of germinal center B-cell formation by developing mathematical models for the dynamics of B-cell somatic hypermutations. We use the...

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Identifiers

PMID: 28092957
DOI: 10.3934/mbe.2017037

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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