Article
Dynein is required for polarized dendritic transport and uniform microtubule orientation in axons.
Nature cell biology - 1 Oct 2008
Zheng Yi, Wildonger Jill, Ye Bing, Zhang Ye, Kita Angela, Younger Susan H, Zimmerman Sabina, Jan Lily Yeh, Jan Yuh Nung
Abstract excerpt
Axons and dendrites differ in both microtubule organization and in the organelles and proteins they contain. Here we show that the microtubule motor dynein has a crucial role in polarized transport and in controlling the orientation of axonal microtubules in Drosophila melanogaster dendritic arborization (da) neurons. Changes in organelle distribution within the dendritic arbors of dynein mutant neurons correlate...
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