Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Local inhibition of microtubule dynamics by dynein is required for neuronal cargo distribution.

Nature communications - 13 Apr 2017

Yogev Shaul, Maeder Celine I, Cooper Roshni, Horowitz Mark, Hendricks Adam G, Shen Kang

Abstract excerpt

Abnormal axonal transport is associated with neuronal disease. We identified a role for DHC-1, the C. elegans dynein heavy chain, in maintaining neuronal cargo distribution. Surprisingly, this does not involve dynein's role as a retrograde motor in cargo transport, hinging instead on its ability to inhibit microtubule (MT) dynamics. Neuronal MTs are highly static, yet the mechanisms and functional significance of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Axonal Transport
Share to Caenorhabditis elegans Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chlorocebus aethiops

Share to Cytoplasmic Dyneins

Share to Dendrites

Share to Microscopy, Confocal

Share to Microtubules

Share to Time-Lapse Imaging

Source

Open in PubMed Open full text

Identifiers

PMID: 28406181
DOI: 10.1038/ncomms15063
PMCID: PMC5399302

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Local inhibition of microtubule dynamics by dynein is required for neuronal cargo distribution.PMID 28406181Read ↗

Mutations in Caenorhabditis elegans cytoplasmic dynein components reveal specificity of neuronal retrograde cargo.Semantic proximity Read ↗

Role of kinesin-1-based microtubule sliding in Drosophila nervous system development.Semantic proximity Read ↗

The Long Haul: Microtubule Motors as the Essential Supply Line for Neuronal Longevity.Semantic proximity Read ↗

Regulators of the actin cytoskeleton mediate lethality in a Caenorhabditis elegans dhc-1 mutant.Semantic proximity Read ↗

PTRN-1, a microtubule minus end-binding CAMSAP homolog, promotes microtubule function in Caenorhabditis elegans neurons.Semantic proximity Read ↗

Loss of MEC-17 leads to microtubule instability and axonal degeneration.Semantic proximity Read ↗

Kinesin-1 regulates dendrite microtubule polarity in Caenorhabditis elegans.Semantic proximity Read ↗

Genetic analysis of dynein function in the nervous system and in mitosisSemantic proximity Read ↗

Dynactin is required for transport initiation from the distal axon.Semantic proximity Read ↗

Cytoplasmic dynein heavy chain: the servant of many masters.Semantic proximity Read ↗

CNS myelination requires cytoplasmic dynein function.Semantic proximity Read ↗

The Caenorhabditis elegans microtubule minus-end binding homolog PTRN-1 stabilizes synapses and neurites.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.