Article
Population pharmacokinetics of metformin in healthy subjects and patients with type 2 diabetes mellitus: simulation of doses according to renal function.
Clinical pharmacokinetics - 1 May 2013
Duong Janna K, Kumar Shaun S, Kirkpatrick Carl M, Greenup Louise C, Arora Manit, Lee Toong C, Timmins Peter, Graham Garry G, Furlong Timothy J, Greenfield Jerry R, Williams Kenneth M, Day Richard O
Abstract excerpt
BACKGROUND AND OBJECTIVE: Metformin is contraindicated in patients with renal impairment; however, there is poor adherence to current dosing guidelines. In addition, the pharmacokinetics of metformin in patients with significant renal impairment are not well described. The aims of this study were to investigate factors influencing the pharmacokinetic variability, including variant transporters, between healthy...
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