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Article

Using a limited sampling strategy to investigate the interindividual pharmacokinetic variability in metformin: A large prospective trial.

British journal of clinical pharmacology - 1 Apr 2021

Kuhlmann Ida, Arnspang Pedersen Sidsel, Skov Esbech Peter, Bjerregaard Stage Tore, Hougaard Christensen Mette Marie, Brøsen Kim

Abstract excerpt

AIMS: Recently a limited sampling strategy (LSS) for determination of metformin' pharmacokinetics was developed. The LSS utilizes the plasma concentration of metformin 3 and 10 hours after oral intake of a single dose to estimate the area under the concentration-time curve up to 24 hours (AUC0-24h ). The main purpose of this study was to support the feasibility of this strategy in a large prospective trial....

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PMID: 33118168
DOI: 10.1111/bcp.14591

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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