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Article

Metoprolol Population Pharmacokinetics in Older Chinese Patients With CKM Syndrome: Joint Effects of rs1065852 and CKM2S2-BAG Score on Clearance.

Clinical and translational science - 1 Aug 2026

Chai Haodi, Sia Jie En Valerie, Hu Dingyuan, Jia Yunshu, Hu Suiyuan, Wu Xinyi, Liu Dongyang, Lai Xuan, Cui Cheng

Abstract excerpt

Older adults are vulnerable to adverse drug reactions due to multimorbidity, frailty and polypharmacy. In those with cardiovascular-kidney-metabolic (CKM) syndrome, CKM-related multi-organ burden may further alter drug disposition and elevate risk. Metoprolol exposure varies widely among individuals, and higher plasma concentrations have been associated with falls in prior studies. We aimed to develop a...

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PMID: 42496093
DOI: 10.1111/cts.70677
PMCID: PMC13398154

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CKM

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