Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of the functional Toll-Like receptor-9 promoter polymorphism (-1237T/C) in increased risk of end-stage renal disease: a case-control study.

PloS one - 1 Jan 2013

Yang Hsin-Yi, Lu Kuo-Cheng, Lee Herng-Sheng, Huang Shih-Ming, Lin Yuh-Feng, Wu Chia-Chao, Salter Donald M, Su Sui-Lung

Abstract excerpt

Inflammation induced by infectious and noninfectious triggers in the kidney may lead to end stage renal disease (ESRD). Toll-like receptor 9 (TLR-9) a receptor for CpG DNA is involved in activation of immune cells in renal disease and may contribute to chronic inflammatory disease progression through an interleukin-6 (IL-6) dependent pathway. Previous studies indicate that -1237T/C confers regulatory effects on...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Disease Progression
Share to HEK293 Cells

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Inflammation

Share to Interleukin-6

Share to Kidney Failure, Chronic

Share to Leukocytes, Mononuclear

Share to Toll-Like Receptor 9

Share to Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 23472199
DOI: 10.1371/journal.pone.0058444
PMCID: PMC3589433

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of the functional Toll-Like receptor-9 promoter polymorphism (-1237T/C) in increased risk of end-stage renal disease: a case-control study.PMID 23472199Read ↗

A functional polymorphism in the promoter region of TLR3 is associated with susceptibility to end-stage renal disease.Semantic proximity Read ↗

The T-1237C polymorphism of the Toll-like receptor-9 gene is associated with chronic kidney disease in a Han Chinese population.Semantic proximity Read ↗

TLR-9 promoter polymorphisms (T-1237C and T-1486C) are not associated with systemic lupus erythematosus: a case control study and meta-analysis.Semantic proximity Read ↗

TLR9 gene polymorphism (rs187084, rs352140): association with acute rejection and estimated glomerular filtration rate in renal transplant recipients.Semantic proximity Read ↗

Genetic polymorphisms located in genes related to immune and inflammatory processes are associated with end-stage renal disease: a preliminary study.Semantic proximity Read ↗

Impact of polymorphisms of TLR4/CD14 and TLR3 on acute rejection in kidney transplantation.Semantic proximity Read ↗

The Variations' in Genes Encoding TIM-3 and Its Ligand, Galectin-9, Influence on ccRCC Risk and Prognosis.Semantic proximity Read ↗

Transcription factor 7-like 2 (TCF7L2) gene polymorphism and clinical phenotype in end-stage renal disease patients.Semantic proximity Read ↗

T-1237C polymorphism of TLR9 gene is not associated with multiple sclerosis in the Portuguese population.Semantic proximity Read ↗

Toll-Like Receptor Family Polymorphisms Are Associated with Primary Renal Diseases but Not with Renal Outcomes Following Kidney Transplantation.Semantic proximity Read ↗

Increase in NF-kappaB binding affinity of the variant C allele of the toll-like receptor 9 -1237T/C polymorphism is associated with Helicobacter pylori-induced gastric disease.Semantic proximity Read ↗

The (-1486T/C) promoter polymorphism of the TLR-9 gene is associated with end-stage knee osteoarthritis in a Chinese population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.