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Article

The (-1486T/C) promoter polymorphism of the TLR-9 gene is associated with end-stage knee osteoarthritis in a Chinese population.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 1 Jan 2012

Su Sui-Lung, Yang Hsin-Yi, Lee Chian-Her, Huang Guo-Shu, Salter Donald M, Lee Herng-Sheng

Abstract excerpt

Based on the recent observation that Toll-like receptors (TLRs) may be involved in the pathogenesis of osteoarthritis (OA) we explored the possibility that human TLR gene polymorphisms are associated with OA. Two separate populations were studied in a two-stage case-control study with a total of...

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Identifiers

PMID: 21748790
DOI: 10.1002/jor.21494

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21748790-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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