Article
Increase in NF-kappaB binding affinity of the variant C allele of the toll-like receptor 9 -1237T/C polymorphism is associated with Helicobacter pylori-induced gastric disease.
Infection and immunity - 1 Mar 2010
Ng Mike Tsz Hin, Van't Hof Rob, Crockett Julie C, Hope Mairi E, Berry Susan, Thomson John, McLean Mairi H, McColl Kenneth E L, El-Omar Emad M, Hold Georgina L
Abstract excerpt
Colonization of the gastric mucosa by Helicobacter pylori can lead to serious clinical outcomes, including gastric cancer. Toll-like receptors (TLRs) play an important role in the host response to H. pylori through the recognition of pathogen-associated molecular patterns. TLR9, in particular, is partly responsible for initiating bacterial induced immunity by binding unmethylated CpG-DNA, which is abundant in...
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