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Article

A functional polymorphism in the promoter region of TLR3 is associated with susceptibility to end-stage renal disease.

American journal of nephrology - 1 Jan 2014

Yang Hsin-Yi, Huang Shih-Ming, Lu Kuo-Cheng, Wu Chia-Chao, Kang Chi-Yu, Lin Yuh-Feng, Lin Chin, Lin Fu-Huang, Kao Sen-Yeong, Su Sui-Lung

Abstract excerpt

BACKGROUND/AIMS: End-stage renal disease (ESRD) is simultaneously associated with immune activation, systemic inflammation and immune deficiency. Toll-like receptor 3 (TLR3), a receptor for viral double-stranded RNA, is involved in immune cell activation in renal diseases and may contribute to chronic inflammatory disease progression. To date, effects of TLR3 polymorphisms on ESRD remain unknown. Therefore, we...

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Source

Identifiers

PMID: 25171218
DOI: 10.1159/000365934

Genes

TLR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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