Article
Toll-Like Receptor Family Polymorphisms Are Associated with Primary Renal Diseases but Not with Renal Outcomes Following Kidney Transplantation.
PloS one - 1 Jan 2015
Dessing Mark C, Kers Jesper, Damman Jeffrey, Leuvenink Henri G D, van Goor Harry, Hillebrands Jan-Luuk, Hepkema Bouke G, Snieder Harold, van den Born Jacob, de Borst Martin H, Bakker Stephan J L, Navis Gerjan J, Ploeg Rutger J, Florquin Sandrine, Seelen Marc, Leemans Jaklien C
Abstract excerpt
Toll-like receptors (TLRs) play a crucial role in innate- and adaptive immunity. The TLR pathways were shown to play key functional roles in experimental acute and chronic kidney injury, including the allo-immune response after experimental renal transplantation. Data about the precise impact of TLRs and their negative regulators on human renal transplant outcomes however are limited and contradictory. We studied...
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