Article
A polymetamorphic protein.
Protein science : a publication of the Protein Society - 1 May 2013
Stewart Katie L, Dodds Eric D, Wysocki Vicki H, Cordes Matthew H J
Abstract excerpt
Arc repressor is a homodimeric protein with a ribbon-helix-helix fold. A single polar-to-hydrophobic substitution (N11L) at a solvent-exposed position leads to population of an alternate dimeric fold in which 3₁₀ helices replace a β-sheet. Here we find that the variant Q9V/N11L/R13V (S-VLV), with two additional polar-to-hydrophobic surface mutations in the same β-sheet, forms a highly stable, reversibly folded...
Topics
- Apoptosis Regulatory Proteins
- Hydrophobic and Hydrophilic Interactions
- Models, Molecular
- Mutation
- Protein Folding
- Protein Multimerization
- Protein Structure, Secondary