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Article

Computational and experimental probes of symmetry mismatches in the Arc repressor-DNA complex.

Journal of molecular biology - 2 Jul 2004

Spector Shari, Sauer Robert T, Tidor Bruce

Abstract excerpt

Arc repressor from bacteriophage P22 is a homodimeric member of the ribbon-helix-helix family of transcription factors. Two dimers bind cooperatively to adjacent sites on operator DNA with the antiparallel beta-sheet of each Arc dimer contacting the major groove. Despite the 2-fold symmetry of the dimer, the sequence of the DNA half-site is not symmetric, and thus there is an inherent symmetry mismatch in the...

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Identifiers

PMID: 15201050
DOI: 10.1016/j.jmb.2004.04.026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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