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Article

Rheostats and toggle switches for modulating protein function.

PloS one - 1 Jan 2013

Meinhardt Sarah, Manley Michael W, Parente Daniel J, Swint-Kruse Liskin

Abstract excerpt

The millions of protein sequences generated by genomics are expected to transform protein engineering and personalized medicine. To achieve these goals, tools for predicting outcomes of amino acid changes must be improved. Currently, advances are hampered by insufficient experimental data about nonconserved amino acid positions. Since the property "nonconserved" is identified using a sequence alignment, we...

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Identifiers

PMID: 24386217
DOI: 10.1371/journal.pone.0083502
PMCID: PMC3875437

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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