Article
Sequence determinants of a conformational switch in a protein structure.
Proceedings of the National Academy of Sciences of the United States of America - 20 Dec 2005
Anderson Thomas A, Cordes Matthew H J, Sauer Robert T
Abstract excerpt
The Arc repressor of bacteriophage P22 is a dimeric member of the ribbon-helix-helix family of transcription factors. Residues 9-14 of each wild-type Arc subunit pair to form two antiparallel beta-strands and have the alternating pattern of polar and nonpolar residues expected for a beta-ribbon with one solvent-exposed face and one face that forms part of the hydrophobic core. Simultaneously switching Asn-11 to...
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