Article
Evolution of oligomeric state through allosteric pathways that mimic ligand binding.
Science (New York, N.Y.) - 19 Dec 2014
Perica Tina, Kondo Yasushi, Tiwari Sandhya P, McLaughlin Stephen H, Kemplen Katherine R, Zhang Xiuwei, Steward Annette, Reuter Nathalie, Clarke Jane, Teichmann Sarah A
Abstract excerpt
Evolution and design of protein complexes are almost always viewed through the lens of amino acid mutations at protein interfaces. We showed previously that residues not involved in the physical interaction between proteins make important contributions to oligomerization by acting indirectly or allosterically. In this work, we sought to investigate the mechanism by which allosteric mutations act, using the...
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