Article
Markovian Backbone Negentropies: Molecular descriptors for protein research. I. Predicting protein stability in Arc repressor mutants.
Proteins - 1 Sept 2004
Ramos de Armas Ronal, González Díaz Humberto, Molina Reinaldo, Uriarte Eugenio
Abstract excerpt
As more and more protein structures are determined and applied to drug manufacture, there is increasing interest in studying their stability. In this sense, developing novel computational methods to predict and study protein stability in relation to their amino acid sequences has become a significant goal in applied Proteomics. In the study described here, Markovian Backbone Negentropies (MBN) have been...
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