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Article

Altering dimerization specificity by changes in surface electrostatics.

Proceedings of the National Academy of Sciences of the United States of America - 13 Mar 2001

Nohaile M J, Hendsch Z S, Tidor B, Sauer R T

Abstract excerpt

Arc repressor forms a homodimer in which the subunits intertwine to create a single globular domain. To obtain Arc sequences that fold preferentially as heterodimers, variants with surface patches of excess positive or negative charge were designed. Several but not all oppositely charged sequence...

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Identifiers

PMID: 11248040
DOI: 10.1073/pnas.051624498
PMCID: PMC30615

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11248040-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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