Predicting stability of Arc repressor mutants with protein stochastic moments.

Abstract excerpt

As more and more protein structures are determined and applied to drug manufacture, there is increasing interest in studying their stability. In this study, the stochastic moments ((SR)pi(k)) of 53 Arc repressor mutants were introduced as molecular descriptors modeling protein stability. The Linear Discriminant Analysis model developed correctly classified 43 out of 53, 81.13% of proteins according to their...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Markov Chains
• Share to Models, Statistical
• Share to Mutation