Neuropeptide S receptor gene is associated with cortisol responses to social stress in humans.

doi:10.1016/j.biopsycho.2013.02.018

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Article

Neuropeptide S receptor gene is associated with cortisol responses to social stress in humans.

Biological psychology - 1 May 2013

Kumsta Robert, Chen Frances S, Pape Hans-Christian, Heinrichs Markus

Abstract excerpt

The neuropeptide S (NPS) and its receptor NPSR represent a transmitter system critically involved in the modulation of anxiety and arousal in rodents. Initial human studies indicate that the T-allele of the functional NPSR gene (NPSR1) polymorphism (rs324981), which increases NPS potency at NPSR, is associated with anxiety-related phenotypes. Since stress is critically involved in the pathogenesis of anxiety...

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Identifiers

PMID: 23466585
DOI: 10.1016/j.biopsycho.2013.02.018

Genes

NPS
NPSR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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