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Article

Sex-specific association between functional neuropeptide S receptor gene (NPSR1) variants and cortisol and central stress responses.

Psychoneuroendocrinology - 1 Feb 2017

Streit Fabian, Akdeniz Ceren, Haddad Leila, Kumsta Robert, Entringer Sonja, Frank Josef, Yim Ilona S, Zänkert Sandra, Witt Stephanie H, Kirsch Peter, Rietschel Marcella, Wüst Stefan

Abstract excerpt

The brain neuropeptide S (NPS) system has recently generated substantial interest and may be of major relevance for central stress regulation. The NPS receptor (NPSR1) is highly expressed in the limbic system, exogenous NPS exerts pronounced anxiolytic and fear-attenuating effects in rodents and extensive close crosstalk between the NPS system and the hypothalamic-pituitary-adrenal (HPA) axis has been...

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Source

Identifiers

PMID: 27883964
DOI: 10.1016/j.psyneuen.2016.10.027

Genes

NPSR1
NPS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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