Role of the neuropeptide S receptor 1 rs324981 polymorphism in modulating emotionality and cognitive flexibility: Insights from a gene-edited mouse model.

doi:10.1016/j.bbr.2025.115530

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Article

Role of the neuropeptide S receptor 1 rs324981 polymorphism in modulating emotionality and cognitive flexibility: Insights from a gene-edited mouse model.

Behavioural brain research - 8 May 2025

Rappeneau Virginie, Tobinski Ann-Marie, Guevara Leonardo Miguel Caisachana, Meyer Neele, Jüngling Kay, Touma Chadi

Abstract excerpt

The neuropeptide S (NPS) and its receptor (NPSR1) are involved in various physiological processes, including arousal, sleep, anxiety, memory, and stress responses in rodents. Recent attention has focused on the association between the NPS/NPSR1 system and stress-related disorders, particularly involving a specific single nucleotide polymorphism (SNP) in the NPSR1 gene (rs324981). This SNP causes an amino acid...

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Identifiers

PMID: 40064355
DOI: 10.1016/j.bbr.2025.115530

Genes

NPSR1
NPS

Variants

rs324981

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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