Neuropeptide-S (NPS) receptor genotype modulates basolateral amygdala responsiveness to aversive stimuli.

doi:10.1038/npp.2011.73

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Article

Neuropeptide-S (NPS) receptor genotype modulates basolateral amygdala responsiveness to aversive stimuli.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Aug 2011

Dannlowski Udo, Kugel Harald, Franke Friederike, Stuhrmann Anja, Hohoff Christa, Zwanzger Peter, Lenzen Thomas, Grotegerd Dominik, Suslow Thomas, Arolt Volker, Heindel Walter, Domschke Katharina

Abstract excerpt

Recent studies point to a role of neuropeptide-S (NPS) in the etiology of anxiety disorders. In animal models, NPS and its receptor (NPSR) were shown to be highly expressed in the amygdala, a central structure in the fear circuit, also known to be hyper-responsive in anxiety disorders. Recently, a functional polymorphism in the NPSR gene (rs324981 A/T) has been associated with panic disorder and anxiety...

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PMID: 21525857
DOI: 10.1038/npp.2011.73
PMCID: PMC3154106

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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