The functional coding variant Asn107Ile of the neuropeptide S receptor gene (NPSR1) is associated with schizophrenia and modulates verbal memory and the acoustic startle response.

doi:10.1017/S1461145711001623

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Article

The functional coding variant Asn107Ile of the neuropeptide S receptor gene (NPSR1) is associated with schizophrenia and modulates verbal memory and the acoustic startle response.

The international journal of neuropsychopharmacology - 1 Oct 2012

Lennertz Leonhard, Quednow Boris B, Schuhmacher Anna, Petrovsky Nadine, Frommann Ingo, Schulze-Rauschenbach Svenja, Landsberg Martin W, Steinbrecher Anja, Höfels Susanne, Pukrop Ralf, Klosterkötter Joachim, Franke Petra E, Wölwer Wolfgang, Gaebel Wolfgang, Häfner Heinz, Maier Wolfgang, Wagner Michael, Mössner Rainald

Abstract excerpt

Recently, the neuropeptide S (NPS) neurotransmitter system has been identified as a promising psychopharmacological drug target given that NPS has shown anxiolytic-like and stress-reducing properties and memory-enhancing effects in rodent models. NPS binds to the G-protein-coupled receptor encoded by the neuropeptide S receptor gene (NPSR1). A functional variant within this gene leads to an amino-acid exchange...

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Identifiers

PMID: 22078257
DOI: 10.1017/S1461145711001623

Genes

NPS
NPSR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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