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Article

Neuropeptide S Receptor 1 variant (I107N) regulates behavioral characteristics and NPS effect in mice in a sex-dependent manner.

Neuropharmacology - 1 Jan 2024

Song Chen, Zhu Zhi-Chen, Liu Chuan-Chuan, Yun Wen-Xin, Wang Zhi-Yuan, Lu Guan-Yi, Song Rui, Wu Ning, Li Jin, Li Fei

Abstract excerpt

Accumulated data demonstrate that the A/T single-nucleotide polymorphism (SNP) rs324981 in the human neuropeptide S receptor 1 (NPSR1) gene, resulting in an amino acid change from asparagine (N) to isoleucine (I) at position 107, is associated with susceptibility to psychiatric disorders. Neuropeptide S (NPS) has also been implicated in modulating these disorders in rodent experiments. However, the effect of this...

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PMID: 37858885
DOI: 10.1016/j.neuropharm.2023.109771

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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