Article
Neuropeptide S receptor gene -- converging evidence for a role in panic disorder.
Molecular psychiatry - 1 Sept 2011
Domschke K, Reif A, Weber H, Richter J, Hohoff C, Ohrmann P, Pedersen A, Bauer J, Suslow T, Kugel H, Heindel W, Baumann C, Klauke B, Jacob C, Maier W, Fritze J, Bandelow B, Krakowitzky P, Rothermundt M, Erhardt A, Binder E B, Holsboer F, Gerlach A L, Kircher T, Lang T, Alpers G W, Ströhle A, Fehm L, Gloster A T, Wittchen H-U, Arolt V, Pauli P, Hamm A, Deckert J
Abstract excerpt
Animal studies have suggested neuropeptide S (NPS) and its receptor (NPSR) to be involved in the pathogenesis of anxiety-related behavior. In this study, a multilevel approach was applied to further elucidate the role of NPS in the etiology of human anxiety. The functional NPSR A/T (Asn¹⁰⁷Ile) variant (rs324981) was investigated for association with (1) panic disorder with and without agoraphobia in two large,...
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