Article
New quantitative trait loci for carotid atherosclerosis identified in an intercross derived from apolipoprotein E-deficient mouse strains.
Physiological genomics - 16 Apr 2013
Rowlan Jessica S, Zhang Zhimin, Wang Qian, Fang Yan, Shi Weibin
Abstract excerpt
Carotid atherosclerosis is the primary cause of ischemic stroke. To identify genetic factors contributing to carotid atherosclerosis, we performed quantitative trait locus (QTL) analysis using female mice derived from an intercross between C57BL/6J (B6) and BALB/cJ (BALB) apolipoprotein E (Apoe(-/-)) mice. We started 266 F(2) mice on a Western diet at 6 wk of age and fed them the diet for 12 wk. Atherosclerotic...
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