Article
Quantitative trait locus analysis of carotid atherosclerosis in an intercross between C57BL/6 and C3H apolipoprotein E-deficient mice.
Stroke - 1 Jan 2008
Li Qiongzhen, Li Yuhua, Zhang Zhimin, Gilbert Timothy R, Matsumoto Alan H, Dobrin Seth E, Shi Weibin
Abstract excerpt
BACKGROUND AND PURPOSE: Inbred mouse strains C57BL/6J (B6) and C3H/HeJ (C3H) exhibit marked differences in atherosclerotic lesion formation in the carotid arteries on the apolipoprotein E-deficient (apoE(-/-)) background when fed a Western diet. Quantitative trait locus analysis was performed on an intercross between B6.apoE(-/-) and C3H.apoE(-/-) mice to determine genetic factors contributing to variation in the...
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