Article
Quantitative trait loci analysis for plasma HDL-cholesterol concentrations and atherosclerosis susceptibility between inbred mouse strains C57BL/6J and 129S1/SvImJ.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jan 2004
Ishimori Naoki, Li Renhua, Kelmenson Peter M, Korstanje Ron, Walsh Kenneth A, Churchill Gary A, Forsman-Semb Kristina, Paigen Beverly
Abstract excerpt
OBJECTIVE: The C57BL/6 (B6) and 129 mouse inbred strains differ markedly in plasma HDL-cholesterol concentrations and atherosclerosis susceptibility after a high-fat diet consumption. To identify loci controlling these traits, we performed quantitative trait loci (QTL) analysis. METHODS AND RESULTS: We fed a high-fat diet to 294 (B6x129S1/SvImJ)F2 females for 14 weeks, measured plasma HDL concentrations and size...
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