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Article

Atherosclerosis susceptibility loci identified from a strain intercross of apolipoprotein E-deficient mice via a high-density genome scan.

Arteriosclerosis, thrombosis, and vascular biology - 1 Mar 2006

Smith Jonathan D, Bhasin Jeffrey M, Baglione Julie, Settle Megan, Xu Yaomin, Barnard John

Abstract excerpt

OBJECTIVE: Apolipoprotein (apo) E-deficient mice are hypercholesterolemic and develop atherosclerosis on low-fat chow diets; however, the genetic background strain has a large effect on atherosclerosis susceptibility. This study aimed to determine the genetic regions associated with strain effects on lesion area. METHODS AND RESULTS: We performed a strain intercross between atherosclerosis sensitive DBA/2 and...

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PMID: 16373612
DOI: 10.1161/01.ATV.0000201044.33220.5c

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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