Article
Quantitative trait locus analysis of neointimal formation in an intercross between C57BL/6 and C3H/HeJ apolipoprotein E-deficient mice.
Circulation. Cardiovascular genetics - 1 Jun 2009
Yuan Zuobiao, Pei Hong, Roberts Drew J, Zhang Zhimin, Rowlan Jessica S, Matsumoto Alan H, Shi Weibin
Abstract excerpt
BACKGROUND: Inbred mouse strains C57BL/6J (B6) and C3H/HeJ (C3H) exhibit marked differences in neointimal formation after arterial injury when deficient in apolipoprotein E (apoE(-/-)) and fed a Western diet. Quantitative trait locus (QTL) analysis was performed on an intercross between B6.apoE(-/-) and C3H.apoE(-/-) mice to determine genetic factors contributing to the phenotype. METHODS AND RESULTS: Female...
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