Article
Cosegregation of aortic root atherosclerosis and intermediate lipid phenotypes on chromosomes 2 and 8 in an intercross of C57BL/6 and BALBc/ByJ low-density lipoprotein receptor-/- mice.
Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 2011
Burkhardt Ralph, Sündermann Simon, Ludwig Doris, Ceglarek Uta, Holdt Lesca M, Thiery Joachim, Teupser Daniel
Abstract excerpt
OBJECTIVE: We sought to identify novel atherosclerosis-modifying loci and their potential functional links in a genome-wide approach using cosegregation analysis of atherosclerosis and related intermediate phenotypes in mice. METHODS AND RESULTS: We carried out an F2 intercross between atherosclerosis-susceptible C57BL/6 mice and atherosclerosis-resistant BALB/cByJ mice on the low-density lipoprotein...
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