Article
Quantitative trait locus analysis of atherosclerosis in an intercross between C57BL/6 and C3H mice carrying the mutant apolipoprotein E gene.
Genetics - 1 Mar 2006
Su Zhiguang, Li Yuhua, James Jessica C, McDuffie Marcia, Matsumoto Alan H, Helm Gregory A, Weber James L, Lusis Aldons J, Shi Weibin
Abstract excerpt
Inbred mouse strains C57BL/6J (B6) and C3H/HeJ (C3H) differ significantly in atherosclerosis susceptibility and plasma lipid levels on the apolipoprotein E-deficient (apoE-/-) background when fed a Western diet. To determine genetic factors contributing to the variations in these phenotypes, we performed quantitative trait locus (QTL) analysis using an intercross between the two strains carrying the apoE-/- gene....
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