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Article

Embryonic germ cells induce epigenetic reprogramming of somatic nucleus in hybrid cells.

The EMBO journal - 3 Nov 1997

Tada M, Tada T, Lefebvre L, Barton S C, Surani M A

Abstract excerpt

Genomic reprogramming of primordial germ cells (PGCs), which includes genome-wide demethylation, prevents aberrant epigenetic modifications from being transmitted to subsequent generations. This process also ensures that homologous chromosomes first acquire an identical epigenetic status before an appropriate switch in the imprintable loci in the female and male germ lines. Embryonic germ (EG) cells have a...

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Identifiers

PMID: 9351832
DOI: 10.1093/emboj/16.21.6510
PMCID: PMC1170256

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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