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Article

Progressive development of polycystic kidney disease in the mouse model expressing Pkd1 extracellular domain.

Human molecular genetics - 15 Jun 2013

Kurbegovic Almira, Trudel Marie

Abstract excerpt

Autosomal dominant polycystic kidney disease (ADPKD) is characterized by slow progression of multiple cysts in both kidneys that lead to renal insufficiency in mid-life or later. ADPKD is associated with mutations mainly in the PKD1 gene (encoding polycystin-1 or PC1) and less frequently in the PKD2 gene (encoding polycystin-2 or PC2). To mimic naturally occurring human PKD1 mutations and gain insight into the...

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Source

Identifiers

PMID: 23439951
DOI: 10.1093/hmg/ddt081

Genes

PKD1
PKD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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