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Article

A polycystin-centric view of cyst formation and disease: the polycystins revisited.

Kidney international - 1 Oct 2015

Ong Albert C M, Harris Peter C

Abstract excerpt

It is 20 years since the identification of PKD1, the major gene mutated in autosomal dominant polycystic kidney disease (ADPKD), followed closely by the cloning of PKD2. These major breakthroughs have led in turn to a period of intense investigation into the function of the two proteins encoded, polycystin-1 and polycystin-2, and how defects in either protein lead to cyst formation and nonrenal phenotypes. In...

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Source

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Identifiers

PMID: 26200945
DOI: 10.1038/ki.2015.207
PMCID: PMC4589452

Genes

PKD1
PKD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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