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Article

Identification of ADPKD-Related Genes and Pathways in Cells Overexpressing PKD2.

Genes - 22 Jan 2020

Zhang Zhe, Dang Yanna, Wang Zizengceng, Wang Huanan, Pan Yuchun, He Jin

Abstract excerpt

Consistent with the gene dosage effect hypothesis, renal cysts can arise in transgenic murine models overexpressing either PKD1 or PKD2, which are causal genes for autosomal dominant polycystic kidney disease (ADPKD). To determine whether PKD gene overexpression is a universal mechanism driving cystogenesis or is merely restricted to rodents, other animal models are required. Previously, we failed to observe any...

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Identifiers

PMID: 31979107
DOI: 10.3390/genes11020122
PMCID: PMC7074416

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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