Article
Cyst formation in kidney via B-Raf signaling in the PKD2 transgenic mice.
The Journal of biological chemistry - 13 Mar 2009
Park Eun Young, Sung Young Hoon, Yang Moon Hee, Noh Ji Yeun, Park So Young, Lee Tae Young, Yook Yeon Joo, Yoo Kyung Hyun, Roh Kyung Jin, Kim Ingyu, Hwang Young-Hwan, Oh Goo Taeg, Seong Je Kyung, Ahn Curie, Lee Han-Woong, Park Jong Hoon
Abstract excerpt
The pathogenic mechanisms of human autosomal dominant polycystic kidney disease (ADPKD) have been well known to include the mutational inactivation of PKD2. Although haploinsufficiency and loss of heterozygosity at the Pkd2 locus can cause cyst formation in mice, polycystin-2 is frequently expressed in the renal cyst of human ADPKD, raising the possibility that deregulated activation of PKD2 may be associated...
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