Article
A human PKD1 transgene generates functional polycystin-1 in mice and is associated with a cystic phenotype.
Human molecular genetics - 1 Nov 2000
Pritchard L, Sloane-Stanley J A, Sharpe J A, Aspinwall R, Lu W, Buckle V, Strmecki L, Walker D, Ward C J, Alpers C E, Zhou J, Wood W G, Harris P C
Abstract excerpt
Three founder transgenic mice were generated with a 108 kb human genomic fragment containing the entire autosomal dominant polycystic kidney disease (ADPKD) gene, PKD1, plus the tuberous sclerosis gene, TSC2. Two lines were established (TPK1 and TPK3) each with approximately 30 copies of the transgene. Both lines produced full-length PKD1 mRNA and polycystin-1 protein that was developmentally regulated, similar...
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